Photodynamic Treatment of Red Blood Cells with Phthalocyanines and Red Light at Higher Light Fluence Rates Is Protective of Red Blood Cells
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چکیده
5,120,649 6/1992 Horowitz et aI 435/173 An improved process for inactivating an extracellular lipid enveloped virus or an intracellular lipid enveloped virus which may be present in an extracorporeal composition containing red blood cells by subjecting the composition to a virucidally effective amount of a phthalocyanine compound and red light of a fiuence rate of at least above about 5 mW/cm• Quite contrary to what would have been expected, it has been found that higher light fiuence rates are, in fact, more protective of red blood cells than are lower light fiuence rates.
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